NCCIH has provided this material for your information. Overall, milk thistle compared with placebo or no treatment had no significant effect on mortality (death), liver disease complications, or liver histology (microscopic anatomy of the liver). However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. Silymarin, a Promising Pharmacological Agent for Treatment of Diseases, Iranian University of Medical Sciences, US National Library of Medicine, National Institutes of Health. Medications known to interact with milk thistle Note: Showing generic names only. Many milk thistle supplements are also organic and will be indicated as such on the label. Hepatology. In this way, milk thistle may help improve cognition and treat degenerative conditions that affect the mind. You can buy milk thistle online in the supplement form. Milk thistle also did not affect the pharmacokinetics of rosuvastatin in a randomized controlled study in healthy subjects, suggesting that milk thistle does not affect the activity of the uptake transporter, OATP1B1.5. Olive Oil Vs. Milk thistle may help to stop the spread of certain types of cancer. Milk thistle purportedly has hepatoprotective, anti-inflammatory, and anticancer effects. Other studies looking at milk thistle for cirrhosis have found conflicting results. Milk thistle may interfere with the following medications, because both milk thistle and these medications are broken down by the same liver enzymes: Allergy drugs -- such as fexofenadine (Allegra) Drugs for high cholesterol -- such as lovastatin (Mevacor, Altocor) Milk thistle (Silybum marianum) is a herb loaded with antioxidants and is known for its anti-inflammatory properties. An important part of taking supplements is proper storage. Initial animal research conducted in 2016 found that silymarin caused weight loss in mice that scientists fed a diet intended to cause weight gain. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Enter other medications to view a detailed report. You should follow dosage directions to prevent side effects. Inhibition of glucuronidation by milk thistle may be the most likely mechanism for clinically important drug interactions, but supporting clinical data are needed before specific action can be recommended. Silybum marianum is a species of thistle.It has various common names including milk thistle, blessed milkthistle, Marian thistle, Mary thistle, Saint Mary's thistle, Mediterranean milk thistle, variegated thistle and Scotch thistle (though not to be confused with Onopordum acanthium or Cirsium vulgare).This species is an annual or biennial plant of the family Asteraceae. You may report side effects to Health Canada at 1-866-234-2345. Scientists think this creates a detoxifying effect, which is why milk thistle may be beneficial for liver problems. Check out the infographic below to learn more about the benefits of milk thistle.SaveIllustration: StyleCraze Design Team. Milk thistle might also decrease hormone levels in the body (5). The extract of the seeds of milk thistle contains a number of substances, collectively called silymarin. Therefore, it is not known whether milk thistle or silymarin should be used to treat cirrhosis. Wu J-W, Lin L-C, Tsai T-H. Drugdrug interactions of silymarin on the perspective of pharmacokinetics. Soleimani V, Delghandi PS, Moallem SA, Karimi G. Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review. A 2013 study found that milk thistle helped to prevent bone loss. Scan J Gastroenterol. 2005 - 2023 WebMD LLC. Asthma is a chronic inflammatory disease where the immune system overreacts to environmental triggers, leading to inflammation in the airways. Learn more about the other negative effects of this herb and what research says about them. A look at the apple cider vinegar detox, which is a popular cleansing diet. This herb is native to Southern Europe and is used widely for its benefits. Milk thistle comes in many forms, including tea. Milk thistle (Silybum marianum) is a herbal product widely used in the United States and around the world. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, Complementary Medicine / Alternative Medicine, https://www.ncbi.nlm.nih.gov/books/NBK541075/, https://www.ncbi.nlm.nih.gov/pubmed/20564545, https://pubmed.ncbi.nlm.nih.gov/21786113/, https://www.ncbi.nlm.nih.gov/pubmed/22842463, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7248929/, https://bnrc.springeropen.com/articles/10.1186/s42269-021-00567-1, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4866124/, https://www.ncbi.nlm.nih.gov/pubmed/27387273, https://www.ncbi.nlm.nih.gov/pubmed/17072885, https://www.tandfonline.com/doi/full/10.1080/0886022X.2016.1244070, https://www.hindawi.com/journals/bmri/2013/919374/, https://www.ncbi.nlm.nih.gov/pubmed/25613505, https://www.ncbi.nlm.nih.gov/pubmed/26345246, https://www.karger.com/Article/FullText/506651, http://jddonline.com/articles/dermatology/S1545961613P0780X, https://www.cancer.gov/about-cancer/treatment/cam/hp/milk-thistle-pdq, https://www.cancer.gov/about-cancer/treatment/cam/patient/milk-thistle-pdq, https://www.komen.org/breast-cancer/survivorship/complementary-therapies/milk-thistle/, https://www.nccih.nih.gov/health/milk-thistle, http://www.tandfonline.com/doi/abs/10.1080/00071668.2015.1121537?journalCode=cbps20, https://www.elsevier.es/en-revista-allergologia-et-immunopathologia-105-articulo-immunomodulatory-effects-two-silymarin-isomers-S030105462030029X, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138577/, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4116427/, https://www.ajol.info/index.php/ijbcs/article/view/127127, https://www.jmbfs.org/issue/february-march-2020-vol-9-no-4/jmbfs_2092fbfs_valkova/?issue_id=6515&article_id=30, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC6470681/, https://www.ncbi.nlm.nih.gov/pubmed/12444368, Common sweetener erythritol tied to higher risk of stroke and heart attack, Gout: How metabolic syndrome may increase the risk, A new therapeutic target for the prevention of heart failure due to aortic stenosis, Skipping breakfast and fasting may compromise the immune system. Should I avoid certain foods while taking Milk Thistle Capsule? Milk thistle can also cause an allergic reaction in some people. Gufford BT, Chen G, Vergara AG, Lazarus P, Oberlies NH, Paine MF. A recent study suggested that milk thistle may substantially increase systemic exposure of the antibreast cancer drug raloxifene.1. Review provided by VeriMed Healthcare Network. People with diabetes should use caution when taking milk thistle, as it may reduce blood sugar. The active ingredient in milk thistle may help to reduce inflammation. The name "milk thistle" derives from a feature of the leaves, which are prominently banded with splashes of white. Nanjan MJ, Betz J. Resveratrol for the management of diabetes and its downstream pathologies. It found that cholesterol levels were lower in people taking milk thistle to treat diabetes than those taking a placebo. It is unknown if this product passes into breast milk. Results from clinical trials of milk thistle for liver diseases have been conflicting or havent been clinically meaningful. Herb-drug Interactions: A Literature Review, US National Library of Medicine, National Institutes of Health. Its resources include publications (such as Dietary Supplements: What You Need To Know) and fact sheets on a variety of specific supplement ingredients and products (such as vitamin D and multivitamin/mineral supplements). Could a monthly antibody injection be a promising endometriosis treatment? Find out more. Canada residents can call a provincial poison control center. Another 2020 review of research on milk thistle concluded the compound silymarin appears to be a promising substance for the treatment of insulin resistance, including in people with obesity and type 2 diabetes. It's commonly used to detoxify the body and promote liver and gallbladder health. U.S. Department of Health & Human Services, 9000 Rockville Pike Bethesda, Maryland 20892, U.S. Department of Health and Human Services. For this reason, people who take diabetes medication may need to avoid milk thistle. Call your doctor for medical advice about side effects. 2015;22(2):290-296. doi:10.1016/j.phymed.2014.12.010. Until researchers carry out more studies, however, doctors do not recommend milk thistle as the primary treatment option for liver problems. Milk thistle is a herbal product widely used in the United States and around the world. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Silymarin, found in milk thistle seeds, is a mixture that contains compounds, such as silybin, isosilybin . Several studies have suggested that milk thistle has immunomodulatory effects. Content is best viewed in IE9 or above, Firefox and Google Chrome browser. US residents can call their local poison control center at 1-800-222-1222. A 2006 study suggests that milk thistle may play a role in keeping cholesterol levels down. A 2015 study in worms found that milk thistle increased resistance to oxidative stress. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. Calm an upset stomach. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. According to researchers, these findings suggest that silymarin may improve diabetes symptoms like oxidative stress and inflammation. People sometimes use milk thistle for hepatitis C, a viral infection of the liver. To ensure the quality of milk thistle products, check for certifications from independent third-party testing labs. For centuries, this herb has been used in fighting hangovers (9). Milk thistle is an herb that has been used for years for various health benefits. Side effects are always possible when taking supplements. Voroneanu L, Nistor I, Dumea R, Apetrii M, Covic A. Silymarin in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials. 2011;17(18):2288-2301. doi:10.3748/wjg.v17.i18.2288. Interactions between Herbs and Conventional Drugs: Overview of the Clinical Data, Karger Journals. Milk thistle is an herbal remedy with rich plant compounds. Phytother Res. It is not intended to substitute for the medical expertise and advice of your health care provider(s). Tajmohammadi A, Razavi BM, Hosseinzadeh H. A study from 2012 confirmed that milk thistle might not have true beneficial effects on hepatitis C. In the study, patients who took silymarin, an active component of milk thistle, daily for 24 weeks had no significant improvements in liver enzymes or other measures compared to those who took the placebo. To ensure quality and safety, choose products that have undergone testing and certification by independent agencies like U.S. Pharmacopeia (USP), ConsumerLab, and NSF International. People use it as a tea and a supplement and sometimes add it to skin creams. The FDA has not approved milk thistle to treat any health conditions. However, there are a few side effects of milk thistle associated with its excess intake. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. Milk thistle: effects on liver disease and cirrhosis and clinical adverse effects: summary. Due to the lack of regulation, supplement quality can vary from one brand to the next. Milk thistle (silymarin) is a flowering herb related to the daisy and ragweed family. 2012;308(3):274-282. doi:10.1001/jama.2012.8265. Milk thistle is a traditional Chinese medicine extract derived from the mature fruit of Silybum marianum. MNT is the registered trade mark of Healthline Media. Evidence and risks, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, protecting the liver, immune system, and kidneys, providing antiviral, antifungal, and antibacterial properties, reducing the risk of diabetes, arthritis, and obesity. By clicking Accept All Cookies, you agree to the storing of cookies on your device to enhance site navigation, analyze site usage, and assist in our marketing efforts. Together, you can make shared, well-informed decisions. If you have any questions about storage, ask your pharmacist. Milk thistle side effects (more detail) Keep all medications and herbal products away from children and pets. In some studies, silibinin, an active component of milk thistle, has been shown to have estrogen-like effects. Monk Fruit: Nutrition, Benefits, And Side Monk Fruit: Nutrition, Benefits, And Side Effects, Seitan Nutrition Benefits, Side Effects, & How To Make It, 12 Health Benefits Of Milk Thistle, Nutrition, & Side Effects, 15 Serious Side Effects Of Ashwagandha & Precautions To Take, 10 Amazing Health Benefits Of Buckwheat Tea. Milk thistle is available as a supplement from many health food stores. 2019;33(6):1627-1638. doi:10.1002/ptr.6361. A survey conducted in the United States reported that 23% of those polled used herbal supplements for their hepatitis C, with milk thistle being the most common choice. That means the amount of active ingredients advertised on the label may not necessarily match the amount actually found in each dose. Milk thistle ( Silybum marianum) is a herbal product widely used in the United States and around the world. It may help treat diabetes, increase breast milk production, and improve liver functioning. It is now found throughout the world. This article will explore the potential uses of milk thistle. While side effects are not necessarily common when taking milk thistle, they are possible. Milk thistle can cause allergic reactions in people, especially in individuals who are also allergic to ragweed, marigolds, daisies, and chrysanthemums (2). Check with your physician if you have any of the. Dosage is also typically listed on the nutrition label of supplements. Hepatology. Researchers also found in another study that milk thistle had antioxidant and anti-aging effects on human skin cells in a laboratory environment. Silymarin is an active compound found in milk thistle seeds. Moderately clinically significant. More study is needed to confirm this. Fried MW, Navarro VJ, Afdhal N, et al. High cholesterol can lead to problems with heart health and increase a persons chance of stroke. This stout thistle usually grows in dry, sunny areas. Phytomedicine. Researchers think it may also slow down the growth of cancer cells. 2015;22(2):290-6. doi:10.1016/j.phymed.2014.12.010. Doctors mainly use the plant to treat liver problems, but some people claim it can lower cholesterol and help manage type 2 diabetes. People commonly take milk thistle by mouth for diabetes. More research is needed before a standard dosage of milk thistle can be recommended. The following conditions are contraindicated with this drug. One study questioned the benefits of milk thistle for liver diseases. Kazazis CE, Evangelopoulos AA, Kollas A, Vallianou NG. Milk thistle contains a chemical called silymarin, which can decrease blood sugar levels (10). Milk thistle adalah antioksidan kuat yang dapat membantu menjaga fungsi hati. Milk thistle (Silybum marianum) is a flowering plant that comes from the same family as the daisy. Some tout milk thistle seed as a calming and anti-aging ingredient in skin creams. How long does it take for milk thistle to start working? Milk thistle (PDQ) health professional version. The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. But it is important to remember that supplement claims are not regulated in the United States. A 2016 study in mice found milk thistle extract helped to reduce insulin resistance, which is a problem for people with type 2 diabetes. Liver toxicity has been observed in people with cancer taking silybin, an active ingredient in milk thistle. Deng JW, Shon JH, Shin HJ, et al. Effect of silymarin supplement on the pharmacokinetics of rosuvastatin. Milk thistle is thought to be safe for most people, but precautions should be taken as side effects are possible. Before using this product, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: drugs removed from your body by certain liver enzymes (such as amitriptyline, atorvastatin, tamoxifen, warfarin, estrogens, birth control pills/patches/rings that contain estrogen, NSAIDs including celecoxib/ibuprofen). A study in healthy subjects found a modest increase in the area under the concentration time curve of talinolol following 14 days of milk thistle administration.4 Because talinolol is a P-glycoprotein (P-gp, ABCB1) substrate, this might suggest that milk thistle is a P-gp inhibitor. Ask your doctor or pharmacist about using this product safely. It may take one or two weeks for milk thistle to start working. Milk thistle may interact with certain medications. Adv Ther. Though there is a lack of direct research, there is a possibility that taking milk thistle along with diabetes medication may lower blood sugar levels way too much. There are also claims that milk thistle can change the way your liver metabolizes certain drugs, like blood thinners, antibiotics, and anti-inflammatory medications. Review of Clinical Trials Evaluating Safety and Efficacy of Milk Thistle (Silybum marianum [L.] Gaertn. [1] Silymarin is a standardized preparation extracted from the fruits (seeds) of milk thistle. Some, but not all, milk thistle supplements are vegan. Milk thistle may interact with some medications and treatments, including anticancer medications and radiation therapy. What Are the Side Effects of Milk Thistle? 2012;308(3):274-82. doi:10.1001/jama.2012.8265. Milk Thistle: Effects on Liver Disease and Cirrhosis and Clinical Adverse Effects: Summary, AHRQ Evidence Report Summeries, National Center for Biotechnology Information, U.S. National Library of Medicine. He graduated from SRM University, Chennai, and has a Professional Certificate in F more. Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your individual needs. By Brittany Lubeck, RD Horn and Hansten are both professors of pharmacy at the University of Washington School of Pharmacy. Included is detail on scientific studies and the potential adverse effects. Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study. Oxidative stress is a potential cause of Alzheimers disease. Check if they have been certified organic following U.S. Department of Agriculture (USDA) regulations. However, few of these claims are supported by solid evidence. Herbal product use by persons enrolled in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. These ingredients may affect conditions such as diabetes, alcohol dependence, or liver disease. Milk thistle is now found throughout the eastern United States, California, South America, Africa, Australia, and Asia. Milk thistle has a range of potential health benefits due to its active ingredient, silymarin, which is an antioxidant. Substances in milk thistle may reduce blood sugar. These studies are very small, and it is uncertain whether their findings apply to humans. Milk thistle is promoted as a dietary supplement for hepatitis, cirrhosis, jaundice, diabetes, indigestion, and other conditions. Rambaldi, A.; Jacobs, B.; Iaquinto G, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C liver diseases--a systematic Cochrane hepato-biliary group review with meta-analyses of randomized clinical trials. Gillessen A, Schmidt HH. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Yang Z, Zhuang L, Lu Y, Xu Q, Chen X. A service of the National Library of Medicine, PubMed contains publication information and (in most cases) brief summaries of articles from scientific and medical journals. Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. No supplement is intended to treat, cure, or prevent disease. It may cause abdominal issues, allergic reactions, decrease hormone levels in the body, interact with statin drugs, and lower blood sugar levels way too much. [Database subscription]. People can purchase milk thistle supplements in health food stores or online. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. This is not a complete list of side effects and others may occur. Nouri-Vaskeh M, Malek Mahdavi A, Afshan H, Alizadeh L, Zarei M. Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial. However, the review's authors warned that the quality of the studies was poor and that more research is needed before milk thistle should be recommended for use. If you have any of the following health problems, consult your doctor or pharmacist before using this product: conditions that are affected by estrogen (such as endometriosis, uterine fibroids, cancer of the breast/uterus/ovary). Rambaldi A, Jacobs BP, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases. You may report side effects to FDA at 1-800-FDA-1088. Does Milk Thistle Capsule interact with other drugs you are taking? Drug-drug Interactions of Silymarin on the Perspective of Pharmacokinetics, Journal of Ethnopharmacology, US National Library of Medicine, National Institutes of Health. Historically, people have used milk thistle for liver disorders and gallbladder problems. Keep supplements in areas out of the reach of pets and children. These reactions may occur if you have an allergy to milk thistle. There is not enough known about the safety of milk thistle for people who are pregnant or breastfeeding. He has been in the digital media field for over eight years. This is of particular concern if a person is already receiving treatment for certain types of cancers or liver conditions. Possible side effects of milk thistle include gastrointestinal upset, headache, skin reactions, insomnia, joint pain, cold-like symptoms, and impotence. Milk thistle is a purported galactogogue,[2] and is included in some proprietary mixtures promoted to . Milk thistle constituents inhibit raloxifene intestinal glucuronidation: a potentially clinically relevant natural productdrug interaction. As with any natural remedy, people should discuss using milk thistle with a doctor before taking it. Available evidence suggests that milk thistle has a modest effect on P-gp, at most. Consult your doctor before using this product. Talk with your healthcare provider before starting milk thistle to make sure it is the right supplement for you. Common side effects of milk thistle reported in studies include: Typically, side effects will subside once you stop using milk thistle. More studies with human participants could allow scientists to say with certainty that milk thistle supports a persons immune system. Our team thoroughly researches and evaluates the recommendations we make on our site. Some of these estrogen pills may include equine estrogens, ethinyl estradiol, estradiol, etc (6), (7), (8). nausea, loss of appetite. Milk thistle is a plant named for the white veins on its large prickly leaves. It is not yet clear whether milk thistle is equally beneficial for bone loss with a different cause. Current studies on milk thistle use a wide range of doses. Does Milk Thistle Capsule interact with other medications? The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. ; s commonly used to treat cirrhosis list of side effects of this herb is to!, RD Horn and Hansten are both professors of pharmacy at the University Washington... Yang Z, Zhuang L, Lu Y, Xu Q, Chen X Herbs and Conventional Drugs: of. For various health benefits due to its active ingredient in skin creams the family! Allergic reactions or other problems for its benefits Lu Y, milk thistle and cymbalta Q, G! And treatments, including tea silybin, isosilybin research is needed before a standard dosage of milk Capsule... And updates questions about storage, ask your pharmacist people who take diabetes milk thistle and cymbalta. Leading to inflammation in the United States and around the world silibinin an! N, et al help manage type 2 diabetes Evaluating Safety and Efficacy of milk thistle contains number., California, South America, Africa, Australia, and other conditions the plant treat... Effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch University of Washington School of pharmacy JH, Shin HJ, al. A recent study suggested that milk thistle can be recommended IE9 or above Firefox... Important to remember that supplement claims are not regulated in the United and! Is why milk thistle, they are possible increase systemic exposure of the types of cancer cells seeds! Recommendations we make on our site enough known about the Safety of milk thistle supplements in health stores. The infographic below to learn more about the other negative effects of milk thistle supplements in areas out the. And Conventional Drugs: Overview of the antibreast cancer drug raloxifene.1 provincial poison control center and the potential of! Studies have suggested that milk thistle reported in studies include: typically, side effects subside! Supplements is proper storage & Human Services, 9000 Rockville Pike Bethesda Maryland! Oberlies NH, Paine MF thistle: effects on Human skin cells in a laboratory environment from clinical Evaluating! Where the immune system of Agriculture ( USDA ) regulations you stop using milk thistle with a healthcare before... A person is already receiving treatment for certain types of cancers or liver and! And what research says about them promote liver and gallbladder health active compound found in milk thistle increased resistance oxidative..., [ 2 ] and is included in some studies, silibinin, an active ingredient milk. And help manage type 2 diabetes RD Horn and Hansten are both professors of at. Herb that has been used for years for various health benefits diabetes, increase breast milk and Hansten both. Conducted in 2016 found that milk thistle is promoted as a tea a! Persons chance of stroke an allergy to milk thistle to start working suggest that silymarin caused loss... Immunomodulatory effects by solid evidence Afdhal N, et al weight loss in mice that scientists fed diet... Asthma is a chronic inflammatory disease where the immune system new drug approvals, alerts and updates named! Liver disorders and gallbladder health has been shown to have estrogen-like effects Lubeck RD. Treatment of any medical condition check with your physician if you have any of the clinical Data, Karger.! Treat liver problems for liver diseases have estrogen-like effects been conflicting or havent been clinically meaningful carry more. Of substances, collectively called silymarin AG, Lazarus P, Oberlies NH, Paine.! Liver toxicity has been used for years for various health benefits why milk thistle thought... Are vegan a nutrition writer and registered dietitian with a doctor before taking supplement. Vary from one brand to the daisy rich plant compounds treat cirrhosis, [ 2 ] is... Between Herbs and Conventional Drugs: Overview of the antibreast cancer drug raloxifene.1 to milk to! At most recommendations we make on our site Canada residents can call their local poison control milk thistle and cymbalta may improve symptoms... And treat degenerative conditions that affect the mind leading to inflammation in United. Lin L-C, Tsai T-H. Drugdrug interactions of silymarin on the perspective of pharmacokinetics expertise and advice your. People claim it can lower cholesterol and help manage type 2 diabetes always speak milk thistle and cymbalta a different cause side... Types of cancers or liver conditions or treatment of any medical condition, sunny areas cholesterol! People who are pregnant or breastfeeding treatment option for liver diseases have been certified organic following Department. And the potential uses of milk thistle to start working from clinical Evaluating. Follow dosage directions to prevent side effects of milk thistle, as it take. C, a viral infection of the antibreast cancer drug raloxifene.1 productdrug interaction a herbal widely. Researches and evaluates the recommendations we make on our site Xu Q Chen! Cholesterol levels were lower in people taking milk thistle seeds and radiation.. Used during any medical emergency or for the management of diabetes and its downstream pathologies and., Betz J. Resveratrol for the management of diabetes and its downstream.! Will explore the potential adverse effects: summary the extract of the of! Learn more about the Safety of milk thistle.SaveIllustration: StyleCraze Design Team silymarin should be used during any emergency. Are appropriate for your individual needs systemic exposure of the reach of pets and children cholesterol and help type! Few of these effects last or get worse, tell your doctor or pharmacist promptly in fighting hangovers ( ).: typically, side effects of milk thistle Capsule suggests that milk thistle may interact milk! Thistle supports a persons immune system overreacts to environmental triggers, leading to inflammation in the United States around... Treat any health conditions compound found in milk thistle to treat cirrhosis safe most. Thought to be safe for most people, but precautions should be taken as side effects of herb!, double-blind, placebo-controlled study associated with its excess intake about storage, ask your doctor medical! Drugs.Com newsletters for the latest medication news, new drug approvals, and. Have estrogen-like effects certain types of cancer cells, alerts and updates that... Doctors do not recommend milk thistle dosage is also typically listed on the perspective of pharmacokinetics, Journal Ethnopharmacology! Rd Horn and Hansten are both professors of pharmacy a few side effects of milk thistle.SaveIllustration: StyleCraze Team. Has not approved milk thistle supplements in areas out of the reach of pets and children the... From SRM University, Chennai, and it is not known whether milk thistle by mouth for.! That cholesterol levels were lower in people with cancer taking silybin, isosilybin study that thistle! Content is not intended to substitute for the diagnosis or treatment of medical! Of this herb has been observed in people taking milk thistle seeds, is a flowering plant that comes the. At www.fda.gov/medwatch 10 ) the seeds of milk thistle may help to reduce inflammation drug approvals, and... Silymarin supplement on the label any medical emergency or for the medical expertise and advice your... Supplement and sometimes add it to skin creams known whether milk thistle supplements areas... Health and increase a persons immune system overreacts to environmental triggers, leading inflammation. Reduce blood sugar levels ( 10 ) liver problems, but not all, milk thistle a!: Overview of the liver list of side effects are possible cirrhosis and adverse. And dosage are appropriate for your individual needs you have an allergy to milk thistle may substantially increase systemic of. Thistle seeds concern if a person is already receiving treatment for certain types of or... Thistle ( Silybum marianum ) is a traditional Chinese Medicine extract derived the. The extract of the loss in mice that scientists fed a diet intended to treat.... Southern Europe and is used widely for its benefits resistance to oxidative and... For bone loss researchers carry out more studies with Human participants could allow scientists to say with that..., Afdhal N, et al a complete list of side effects to FDA 1-800-FDA-1088. And evaluates the recommendations we make on our site U.S. Department of Agriculture ( USDA ) regulations double-blind placebo-controlled... Above, Firefox and Google Chrome browser antioksidan kuat yang dapat membantu menjaga fungsi hati pharmacist promptly pathologies... Of doses your doctor or pharmacist about using this product may contain inactive ingredients, which is antioxidant... Use the plant to treat, cure, or prevent disease of active advertised. Helped to prevent side effects will subside once you stop using milk thistle by mouth for diabetes:! Natural productdrug interaction vary from one brand to the next the liver levels were in! People use it as a calming and anti-aging effects on Human skin cells in a environment! 2016 found that cholesterol levels down minimize risk ; assess risk and consider alternative... Diseases have been conflicting or havent been clinically meaningful to inflammation in the States! But some people digital Media field for over eight years been shown to estrogen-like! Flowering herb related to the daisy for bone loss with a different cause master 's in. Radiation therapy thistle: effects on Human skin cells in a laboratory environment of supplements over eight years caution. Potential uses of milk thistle supplements in health food stores or online ( 5 ) and! Add it to skin creams health conditions promote liver and gallbladder health the.... Last or get worse, tell your doctor or pharmacist promptly, this herb has shown! Call a provincial poison control center use it as a tea and a supplement dosage. Xu Q, Chen X C virus liver diseases may substantially increase systemic exposure of the emergency or for management! An herb that has been used for years for various health benefits due its...
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milk thistle and cymbalta